gene

OXIDATIVE STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9722Connections

6Hypotheses

7Analyses

50Outgoing

50Incoming

1Experiments

11Debates

Summary

OXIDATIVE STRESS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 3134 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OXIDATIVE STRESS
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compounds	AFMK, CARBIDOPA, CURCUMIN, DAPAGLIFLOZIN, DIMETHYL FUMARATE, DONEPEZIL
Interactions	6-OHDA, ABCD1, ABCD2, ABCD3, ABCG2, ACC
KG Connections	5104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALS["ALS"]
        SOD1["SOD1"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        P62["P62"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AKT["AKT"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    subgraph Therapeutic["Therapeutic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Als["Als"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Diabetes["Diabetes"]
    end
    subgraph Signaling["Signaling"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Inflammation["Inflammation"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Autophagy["Autophagy"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Epigenetic["Epigenetic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
        AUTOPHAGY_1["AUTOPHAGY"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        APOPTOSIS["APOPTOSIS"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3767)

Target	Relation	Type	Str
Ischemia	inhibits	disease	1.00
Diabetes	regulates	disease	1.00
NRF2	inhibits	gene	1.00
Als	inhibits	disease	1.00
Parkinson	therapeutic_target	disease	1.00
Oxidative Stress	inhibits	pathway	1.00
BCL-2	activates	gene	1.00
Neuroinflammation	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
Aging	therapeutic_target	disease	1.00
Als	expressed_in	disease	1.00
Mitophagy	regulates	pathway	1.00
Ferroptosis	activates	pathway	1.00
HO-1	activates	gene	1.00
Stem Cell	activates	pathway	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
Mitochondrial Function	regulates	pathway	1.00
AGING	associated_with	gene	1.00
Oxidative Stress	associated_with	pathway	1.00
AUTOPHAGY	regulates	gene	1.00
DIABETES MELLITUS	therapeutic_target	gene	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Inflammation	causes	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
MITOCHONDRIA	inhibits	gene	1.00
PI3K	inhibits	gene	1.00
Differentiation	activates	pathway	1.00
NF-ΚB	inhibits	gene	1.00
IL-6	inhibits	gene	1.00
AKT	inhibits	gene	1.00
Cardiac	therapeutic_target	disease	1.00
MITOCHONDRIAL DYSFUNCTION	causes	gene	1.00
P62	activates	gene	1.00
NRF2	regulates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
Als	treats	disease	1.00
PARKINSON	associated_with	gene	1.00
PI3K	therapeutic_target	gene	1.00
MTOR	activates	gene	1.00
Alzheimer	activates	disease	1.00
UBIQUITIN	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	treats	gene	1.00
Als	biomarker_for	disease	1.00
INFLAMMATION	causes	gene	1.00
Cardiovascular	regulates	disease	1.00

Incoming (5955)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
Cardiovascular	activates	disease	1.00
Als	expressed_in	disease	1.00
AUTOPHAGY	activates	gene	1.00
Obesity	activates	disease	1.00
Fibrosis	activates	disease	1.00
INFLAMMATION	associated_with	gene	1.00
Aging	inhibits	disease	1.00
TNF	inhibits	gene	1.00
Als	activates	disease	1.00
AKT	activates	gene	1.00
Als	inhibits	disease	1.00
Cancer	regulates	disease	1.00
LC3	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
ROS	associated_with	gene	1.00
TNF	therapeutic_target	gene	1.00
Als	regulates	disease	1.00
MITOPHAGY	associated_with	gene	1.00
Tumor	regulates	disease	1.00
Inflammation	activates	disease	1.00
CANCER	associated_with	gene	1.00
Neurodegeneration	associated_with	disease	1.00
Inflammation	inhibits	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
Ischemia	inhibits	disease	1.00
Parkinson	associated_with	disease	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
Diabetes	therapeutic_target	disease	1.00
PI3K	activates	gene	1.00
DNA	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
OXIDATIVE STRESS	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
Neuroinflammation	associated_with	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
Senescence	associated_with	disease	1.00
NEURODEGENERATION	associated_with	gene	1.00
Aging	activates	disease	1.00
NRF2	inhibits	gene	1.00
Als	associated_with	disease	1.00
Aging	associated_with	disease	1.00
ROS	associated_with	gene	1.00
FERROPTOSIS	associated_with	gene	1.00
Inflammation	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Unde	0.700	neurodegeneration	Investigate mechanisms of epigenetic rep
NRF2-Mediated Proteostatic Convergence: Shared Oxidative Str	0.700	neurodegeneration	-
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
NRF2 Activation to Counteract Oxidative Stress from RGS6 Def	0.518	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
XOR+ stress-responsive astrocytes represent a novel AD-assoc	0.380	Alzheimer's disease	-

Astrocyte-specific autophagy deficiency induces NADPH oxidas	0.380	ALS	How do non-cell autonomous effects of au

Mentioning Analyses (7)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
In midlife, lower Aβ42:Aβ40 ratio was associated with increased risk o	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (11)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning OXIDATIVE STRESS in their description or question text

Astrocyte-specific autophagy deficiency induces NADPH oxidase-mediated oxidative

Score: 0.380 · ALS · 2026-04-27

We hypothesize that autophagy dysfunction specifically in astrocytes induces motor neuron toxicity through impaired mito